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Factor II assay
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Factor II assay

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Prothrombin

The factor II assay is a test to measure the activity of factor II. This is a substance that is involved in blood clotting (coagulation).

I Would Like to Learn About:

  • How the Test is Performed

    A sample of blood will be taken from your vein.

  • How to Prepare for the Test

    No special steps are needed to prepare for this test.

  • How the Test will Feel

    You may feel slight pain or a sting when the needle is inserted to draw blood. You may feel some throbbing afterward

  • Why the Test is Performed

    This test is used to find the cause of too much bleeding (decreased blood clotting). This decreased clotting may be caused by abnormally low levels of factor II.

  • Normal Results

    The value should be 50 - 200% of the laboratory control or reference value.

    Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

    The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

  • What Abnormal Results Mean

    Decreased factor II activity may be the result of:

    • Deficiency of factor II that is present at birth (congenital)
    • Disseminated intravascular coagulation (DIC)
    • Fat malabsorption
    • Liver disease (such as cirrhosis)
    • Vitamin K deficiency
    • Warfarin (Coumadin) use
  • Risks

    Veins and arteries vary in size so it may be harder to take a blood sample from one person than another.

    Other slight risks associated with having blood drawn may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

    This test is most often performed on people who have bleeding problems. The risk of excessive bleeding is slightly greater than for people without bleeding problems.

  • Considerations

    When you bleed, the body starts a chain of activities to help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors (factor II is a coagulation factor).

    Each factor's reaction triggers the next reaction. The final product of the coagulation cascade is the blood clot. Blood clots may not form normally if any one of the clotting factors is too low.

Related Information

  Factor II deficien...MalabsorptionLiver diseaseCirrhosisVitamin K     CirrhosisVitamins

References

Ragni MV. Hemorrhagic Disorders: Coagulation Factor Deficiencies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 177.

Gailani D, Neff AT. Rare Coagulation Deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 139.

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Review Date: 3/3/2013  

Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

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