The doctors can do a procedure to remove platelets directly from the blood if you have life-threatening complications.
Long-term, you will need to take medicines to decrease the platelet count and avoid complications. The most common of these medicines are hydroxyurea, interferon-alpha, or anagrelide. In some people with a JAK2 mutation, specific inhibitors of the JAK2 protein may be used.
In people who are at a high risk for clotting, aspirin at a low dose (81 to 100 mg per day) decreases clotting episodes. People who may benefit from this treatment include older persons and people with very high platelet levels or who have had past clotting episodes.
Many people do not need any treatment. However, the health care provider should monitor your condition.